Nucleic Acids

Nucleic Acids: The Molecular Blueprint of Life

Nucleic Acid Definition:

Nucleic acids are complex biomolecules that store and transmit genetic information in living organisms. They are composed of long chains of monomers called nucleotides, which are linked together by phosphodiester bonds. Each nucleotide consists of three main components:

1. Nitrogenous base: The nitrogenous base is a heterocyclic aromatic compound that forms the core of the nucleotide. There are four types of nitrogenous bases: adenine (A), guanine (G), cytosine (C), and thymine (T) in DNA, and uracil (U) instead of thymine in RNA. Adenine and Guanine are purines and Cytosine, Thymine, and Uracil are pyrimidines.

2. Pentose sugar: The pentose sugar is a five-carbon sugar that provides the backbone of the nucleotide chain. In DNA, the pentose sugar is deoxyribose, while in RNA, it is ribose.

3. Phosphate group: The phosphate group is a negatively charged inorganic group that links the nucleotides together to form the phosphodiester backbone of the nucleic acid chain.

There are two main types of nucleic acids: deoxyribonucleic acid (DNA) and ribonucleic acid (RNA).

Types of Nucleic Acids:

  1. DNA (Deoxyribonucleic Acid):

    • Structure: DNA is a double-stranded helical molecule. Each strand consists of a sugar-phosphate backbone and nitrogenous bases (adenine, thymine, guanine, and cytosine).
    • Function: DNA serves as the hereditary material that contains genetic instructions for the development, functioning, and reproduction of all known living organisms.
  2. RNA (Ribonucleic Acid):

    • Structure: RNA is usually single-stranded and contains a sugar-phosphate backbone and nitrogenous bases (adenine, uracil, guanine, and cytosine).
    • Function: RNA plays various roles, including serving as a messenger in protein synthesis (mRNA), transferring amino acids during protein synthesis (tRNA), and catalyzing chemical reactions (ribozymes).


Functions of Nucleic Acids

Nucleic acids play a crucial role in various cellular processes, including:

  1. Storage of genetic information: Nucleic acids store the genetic information that determines the characteristics and traits of an organism.

  2. Protein synthesis: Nucleic acids are involved in the process of protein synthesis, which is the production of proteins from amino acids.

  3. Cell division: Nucleic acids are replicated during cell division to ensure that each daughter cell receives a complete copy of the genetic information.

  4. Regulation of gene expression: Nucleic acids regulate the expression of genes, controlling which genes are turned on or off at specific times and in specific cells.

  5. Mutation and evolution: Mutations in nucleic acids can lead to changes in genetic information, which can result in variations in traits and can contribute to the process of evolution.